Automates bead-based nucleic acid purification for Next Generation Sequencing (NGS) and PCR. Based on our revolutionary and patented centrifugal liquid evacuation technology, the G.PURE increases data quality and reduces cost and timelines in high-throughput NGS sample preparation workflows. Compatible with 96- and 384-well PCR microplates, it enables efficient and automated purification of nucleic acids using ferromagnetic beads – without consuming hundreds of pipette tips, allowing you to process an entire 384-plate in under 2 minutes for rapid and efficient workflow. Ideal for automated DNA cleanup, nucleic acid isolation, and size selection in PCR and NGS library preparation workflows, it delivers high-quality results in molecular biology laboratories. With its non-contact liquid removal and dispensing technology and low residual volume the G.PURE is compatible with all common NGS library preparation protocols and bead types. The ability to cleanup hundreds of samples within minutes without consuming pipette tips makes it an ideal solution for high throughput NGS workflows and single-cell sequencing applications such as SMART-seq.

Key Features & Benefits

1.Non-contact bead cleanup

G.PURE employs centrifugal technology for non-contact liquid removal and dispensing, which effectively minimizes DNA carry-over and contamination. DNA cleanup using G.PURE has never been faster: remove the beads supernatant, and perform 2 washes of ethanol, without a single pipette tip, and in only 2 minutes.

2.Supports multiple plate sizes

Experience enhanced nucleic acid purification capabilities with the G.PURE. This advanced system not only enables efficient purification from 96-well PCR plates but also empowers you to greater throughput by extending its functionality to 384-well PCR plates. For higher volume (e.g in 96-well plate format) the new optimized G.PURE magnets ensure a rapid bead capture (<1 min)

3.Low residual volume

The G.PURE ensures complete liquid removal with residual volumes <0.1 µl, resulting in ultra-pure target DNA. Precise control over final ethanol evaporation: consistent plate to plate operation: beads too dry or too much residual ethanol? G.PURE offers a fast and consistent drying of beads across all samples results in improved library quality. Program the drying step with our protocol editor.

4.Environmentally Friendly

Make a positive impact on your lab's environmental footprint with the G.PURE. Minimize the usage of pipette and liquid handler tips and utilize The Tip Consumption Calculatorto visualize the eco-friendly benefits.

5.Compatible with common NGS protocols

Effortlessly purify and size-select your amplified PCR reactions, DNA, or RNA libraries with the G.PURE, ensuring the removal of unwanted fragments and contaminants. Compatible with all common protocols (i.e. SMART-seq3, FLASH-seq) and bead types (AMPure XP, Mag-Bind® TotalPure NGS…), and more, it offers seamless integration into your workflow.

6.Fast and automated

Experience rapid and streamlined library cleanup with the new G.PURE magnetic carriers. This fully automated and stand-alone system completes the process in under 2 minutes for 96- or 384-well plates, freeing up your valuable time to focus on critical quality control steps.

Product Applications

1.DNA Purification

Ferromagnetic beads have become the gold standard for DNA cleanup in molecular biology applications such as next-generation sequencing (NGS), polymerase chain reaction (PCR), quantitative PCR (qPCR), droplet digital PCR (ddPCR), and other amplification and genotyping techniques. Their effectiveness in nucleic acid isolation and purification, including DNA, RNA, plasmids, and mitochondrial DNA, is widely recognized. Furthermore, ferromagnetic beads are highly valuable for size selection, allowing researchers to isolate specific DNA fragments based on their size range. The G.PURE's compatibility with ferromagnetic bead-based protocols makes it an ideal solution for nucleic acid purification and size selection.

2.Single cell sequencing

The increasing popularity of single-cell sequencing and the reduced cost of high-throughput sequencing have led to a significant rise in the number of samples requiring processing. The G.PURE is designed to meet these demands, offering automation and compatibility to handle larger sample volumes efficiently, notably on the 384-format.

3.Protein isolation

Beyond nucleic acid applications, ferromagnetic beads also play a crucial role in protein purification. They enable the capture and isolation of target proteins from complex samples. The G.PURE's compatibility with ferromagnetic bead-based protocols extends its utility to protein purification workflows, ensuring streamlined and reliable protein isolation.